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Laboratory of Functional and Molecular Imaging

Alan P. Koretsky, Ph.D.

Senior Investigator


Building 10 Room B1D728
10 Center Drive MSC 1065
Bethesda MD 20892-1065
Office: (301) 402-9659
Lab: (301) 402-9659
Fax: (301) 480-2558
koretskya@ninds.nih.gov

Dr. Koretsky received his B.S. degree from the Massachusetts Institute of Technology and Ph.D. from the University of California at Berkeley. He performed postdoctoral work in the NHLBI at NIH studying regulation of mitochondrial metabolism using optical and NMR techniques. Dr. Koretsky spent twelve years on the faculty in the Department of Biological Sciences at Carnegie Mellon University where he was the Eberly Professor of Structural Biology and Chemistry. In summer 1999, he moved to NINDS as Chief of the Laboratory of Functional and Molecular Imaging and Director of the NIH MRI Research Facility. Dr. Koretsky's laboratory is interested in two main areas. They are actively developing novel imaging techniques to visualize brain function and study the regulation of cellular energy metabolism combining molecular genetics with non-invasive imaging tools.

The Functional and Molecular Imaging Section has two major research interests. One is to develop novel functional and molecular imaging techniques to study brain structure and function. Emphasis is on MRI but some optical imaging is performed as well. Current areas of interest are to extend spatial resolution and understand the relation of functional MRI to neuronal architecture. New imaging tools are being developed to image calcium influx and gene expression non-invasively in the mouse brain.

The second major research area is cellular energetics. In particular, we are interested in the role of the enzyme creatine kinase and regulation of mitochondrial metabolism. This work relies on combining non-invasive imaging tools and molecular genetics in the mouse to study mitochondrial function in vivo. Current areas of interest are to determine the role of creatine kinase in cell growth and death. We are also interested in characterizing changes in the mitochondrial proteome during changes in mitochondrial metabolism using novel two-dimensional gel electrophoresis techniques.

Staff Image
  • Tatjana Atanasijevic, Ph.D.
    Visiting Fellow
    Phone : (301) 435-4362
    Email : atanasijevict@ninds.nih.gov

  • Nadia Bouraoud
    Animal Biologist
    Phone : (301) 451-9938
    Email : bouraoudn@ninds.nih.gov

  • Der-Yow Chen, Ph.D.
    Research Fellow
    Phone : (301) 594-7314
    Email : chendy@ninds.nih.gov

  • Yun Chen, Ph.D.
    IRTA
    Phone : (301) 402-1329
    Email : chenyun2@ninds.nih.gov

  • Steve Dodd, Ph.D.
    Staff Scientist
    Phone : (301) 402-0389
    Email : doddst@ninds.nih.gov

  • Raymond Mirasol
    Pre-doctoral IRTA
    Phone : (301) 451-9936
    Email : mirasolrv@ninds.nih.gov

  • Benjamin Porter, Ph.D.
    IRTA Fellow
    Phone : (301) 594-0365
    Email : porterba@ninds.nih.gov

  • Nikorn Pothayee, Ph.D.
    Visiting Fellow
    Phone : (301) 402-9709
    Email : pothayeen@ninds.nih.gov

  • Chunqi Qian, Ph.D.
    Research Fellow
    Phone : (301) 435-2146
    Email : qianc2@ninds.nih.gov

  • Galit Saar, Ph.D.
    Visiting Fellow
    Phone : (301) 451-9913
    Email : saarg@ninds.nih.gov

  • Kathryn Sharer
    Animal Biologist
    Phone : (301) 402-9652
    Email : sharerk@ninds.nih.gov

  • Xin Yu, Ph.D.
    Research Fellow
    Phone : (301) 594-7311
    Email : yuxin@ninds.nih.gov

  • Gary Zabow, Ph.D.
    Senior Research Fellow
    Phone : (301) 594-2133
    Email : zabowg@ninds.nih.gov

  • 1) G. Zabow, S. J. Dodd, E. Shapiro, J. Moreland, and A.P. Koretsky (2011)
  • Microfabricated High-Moment Micrometer Sized MRI Contrast Agents
  • Magn Resonan. Med, 65, 645-655
  • 2) T.C, Hu, K.H. Chuang, N. Yanasak, and A.P. Koretsky (2011)
  • Relationship Between Blood and Myocardial Manganese Levels During Manganese-Enhanced MRII (MERI) with T1 Mapping in Rats
  • NMR Biomed , 24, 46-53
  • 3) S.E. Day, M.I. Kettunen, M.K. Cherukuri, J.B, Michell, M.J. Lizak, H.D. Morris, S. Matsumoto, A.P. Koretsky, and K.M. Brindle (2011)
  • Detecting Response of Rat C6 Glioma Tumors to Radiotherapy using Hyperpolarized [1-(13)C]pyruvate and (13)C Magnetic Resonance Spectroscopic Imaging
  • Magn Resonan Med , 65, 557-563
  • 4) Y. Chen, S. Guzik, J.P. Sumner, J. Moreland, and A.P. Koretsky (2011)
  • Magnetic Manipulation of Actin Orientation, Polymerization and Gliding on Myosin using Superparamagnetc Iron Oxide Particles
  • Nanotechnology , 22
  • 5) J.P. Munasinghe, M. Banerjee, M.T. Acosta, M. Banks, A. heffer, A.C. Silva, A.P. Koretsky, W.H. Theodore (2010)
  • Arterial Spin Labeling Demonstrates that Focal Amygdalar Glutamatergic Agonist Infusion Leads to Rapid Diffuse Cerebral Activation
  • Acta Neurolo Scand, 121, 209-216
  • 6) J.P. Munasinghe, M. Banerjee, M.T. Acosta, M. Banks, A. heffer, A.C. Silva, A.P. Koretsky, W.H. Theodore (2010)
  • Arterial Spin Labeling Demonstrates that Focal Amygdalar Glutamatergic Agonist Infusion Leads to Rapid Diffuse Cerebral Activation
  • Acta Neurolo Scand, 121, 209-216
  • 7) C. Wu, S. Dodd, and A.P. Koretsky (2010)
  • In vivo visualization of Cortical Boundaries in the Rodent Brain using Manganese Enhanced MRI as a Cytoarchitectonic Marker
  • 8) X. Yu, S. Wang, D-Y Chen, S. Dodd, A. Goloshevsky, and A.P. Koretsky (2010)
  • 3D Mapping of Somatotopic Reorganization with Small Animal Functional MRI
  • Neuroimage , 49, 1667-1676
  • 9) R.S. Conroy, A.P. Koretsky, and J. Moreland (2010)
  • Lambda Exonuclease Digestion of CGG Trinulcoetide Repeats
  • Eur. J. Biophys, 39, 337-343
  • 10) K-H Chuang, L. Belluscio, and A.P. Koretsky (2010)
  • In vivo Detection of Individual Glomeruli in the Rodent Olfactory Bulb Using Manganese Enhanced MRI
  • Neuroimage, 49, 1350-1356
  • 11) X. Yu, S. Wang, D-Y Chen, S. Dodd, A. Goloshevsky, and A.P. Koretsky (2010)
  • 3D Mapping of Somatotopic Reorganization with Small Animal Functional MRI
  • Neuroimage, 49, 1667-1676
  • 12) J.P. Munasinghe, M. Banerjee, M.T. Acosta, M. Banks, A. heffer, A.C. Silva, A.P. Koretsky, W.H. Theodore (2010)
  • Arterial Spin Labeling Demonstrates that Focal Amygdalar Glutamatergic Agonist Infusion Leads to Rapid Diffuse Cerebral Activation
  • Acta Neurolo Scand, 121, 209-216
  • 13) J.P. Munasinghe, M. Banerjee, M.T. Acosta, M. Banks, A. heffer, A.C. Silva, A.P. Koretsky, W.H. Theodore (2010)
  • Arterial Spin Labeling Demonstrates that Focal Amygdalar Glutamatergic Agonist Infusion Leads to Rapid Diffuse Cerebral Activation
  • Acta Neurolo Scand, 121, 209-216
  • 14) Y.C. Lee, J. Tucciarone, A.P. Koretsky, and K. Krishnan submitted. (2010)
  • Dissolution of MnO Nanocrystals for MRI-T1 Contrast Agents
  • 15) K-H Chuang, L. Belluscio, and A.P. Koretsky (2010)
  • In vivo Detection of Individual Glomeruli in the Rodent Olfactory Bulb Using Manganese Enhanced MRI
  • Neuroimage, 49, 1350-1356
  • 16) K.H. Chuang, A.P. Koretsky, and C.H. Sotak (2009)
  • Temporal Changes in the T1 and T2 Relaxation Rated ( R1 and R2) in the Rat Brain are Consistent with the Tissue-Clearance Rates of Elemental Manganese
  • Magn Resonan Med , 61, 1528-1532
  • 17) J.J. Yin, K. tracy, J. Munasinghe, E. Shapiro, A.P. Koretsky and K. Kelley (2009)
  • Noninvasive Imaging of the Functional Effects of anti-VEGF Therapy on Tumor Cell Extravasation and Regional Blood Volume in an Experimental Brain Metastasis Model
  • Clinical Experimental Metastasis , 26, 403-414
  • 18) G. Zabow, , A.P Koretsky, and J. Moreland (2009)
  • Design and fabrication of a Micromachined, Multi-Spectral Magnetic Resonance Imaging Agent
  • Journal of Micromechanics and Microengineering , 19, 025020+10
  • 19) K.H. Chuang and A.P. Koretsky (2009)
  • Accounting for Nonspecific Enhancement in Neuronal Tract Tracing Using Manganese Enhanced MRI
  • Magnetic Resonance Imaging, 27, 594-600
  • 20) S. Wang, J. Murphy-Boesch, H. Merkle, A.P. Koretsky, and J. Duyn (2009)
  • B1 Homogenization in MRI by Multilayered Coupled Coils
  • IEEE Trans Med. Imaging , 28, 551-554
  • 21) K.H. Chuang, J.H. Lee, A.C. Silva, L. Belluscio, and A.P. Koretsky. (2009)
  • Manganese Enhanced MRI Reveals Functional Circuitry in Response to Odorant Stimuli
  • Neuroimage, 44, 363-372
  • 22) J. Tucciarone, K-H Chuang, S.J. Dodd, A. Silva, G. Pelled, and A.P. Koretsky (2009)
  • Layer Specific Tracing of Corticocortical and Thalamocortical Connectivity in the Rodent Using Manganese Enhanced MRI
  • Neuroimage, 44, 923-931
  • 23) P. Sumner, E.M. Shapiro, D. Maric, R. Conroy, and A.P. Koretsky (2009)
  • In vivo Labeling of Adult Neural Progenitors for MRI with Micron Sized Particles of Iron Oxide: Quantitation of Labeled Cell Phenotype J
  • Neuroimage , 44, 671-678
  • 24) A. Androutsellis-Theotokis, M. Rueger, D. Park, H. Mkhikian, E. Korb, S. Poser, S. Walbridge, J. Munasinghe, A. Koretsky, R. Lonser, and R. McKay (2009)
  • Targeting Neural Precursors in the Adult Brain Rescues Injured Dopamine Neurons
  • Proc. Natl. Acad. Sci USA , 106 , 13570-13575
  • 25) G. Pelled, D.A. Bergstrom, P.L. Tierney, R. Conroy, K.H. Chuang, D. Yu, D. Leopold, J.A. Walters and A.P. Koretsky, A.P. (2009)
  • Ipsilateral Cortical fMRI Responses Following Peripheral Nerve Damage in Rats Reflects Interneuron Mediated Inhibition
  • Proc. Natl. Acad. Sci USA, 106, 14114-14119
  • 26) G. Zabow, S. Dodd, J. Moreland, and A.P. Koretsky (2009)
  • The fabrication of uniform cylindrical magnetic nanoshells and their use as spectrally tunable MRI Contrast Agents
  • Nanotechnology , 20, 385301
  • 27) C. Du, M. Tully, N.D. volkow, W.K. Schiffer, M. Yu, Z. Luo, A.P. Kroetsky and H. Benveniste (2009)
  • Differential effects of Anesthetics on Cocaine's Pharmacokinetic and Pharmacodynamic Effects in Brain
  • Eur. J. Neurosci. , 30, 1565-1575
  • 28) T.Q. Li, B. Yao, P. van Gelderen, H. Merkle, S. Dodd, L. Talagala, A.P. Koretsky, and J. Duyn (2009)
  • Chartacterization of T2* Heterogeniety in Human Brain White Matter
  • Magn Resonan Med , 9, 1652-1657
  • 29) R.S. Conroy, G. Zabow, J. Moreland, and A.P. Koretsky (2008)
  • Controlled Transport of Magnetic Particles Using Soft Magnetic Patterns
  • Applied Physics Lett, 93, 203901-1-3
  • 30) K.M. Bennett, H. Zhou, J.P. Sumner, S.J. Dodd, N. Bouraoud, K. Doi, R.A. Star, and A.P. Koretsky (2008)
  • MRI of the basement membrane using charged nanoparticles as contrast agents
  • Magn Resonan Med, 60, 564-574
  • 31) G. Goelman, G. Pelled, S. Dodd, and A.P. Koretsky (2008)
  • Tracking the Effects of Crusher Gradients on Gradient-Echo Bold Signal in Space and Time During Rat Sensory Stimulation
  • Magn. Resonan. Med, 60 , 548-554
  • 32) E.M. Shapiro and A.P. Koretsky (2008)
  • Convertible Manganese Contrast for Molecular and Cellular MRI
  • Magn Resonan Med, 60, 265-269
  • 33) J.M . Simmons, Z.S. Saad, M.J. Lizak, M. Ortiz, A.P. Koretsky and B. J. Richmond. (2008)
  • Mapping Prefrontal Circuits in vivo with Manganese-Enhanced MRI in Monkeys
  • J. Neurosci , 28, 7637-7647
  • 34) C. Sotak, K. Sharer, and A.P. Koretsky (2008)
  • Manganese cell Labeling of Murine Hepatocytes Using Manganese(III)-Transferrin
  • Contast Med. Mol. Imaging , 3, 95-105
  • 35) J. H. Duyn and A.P. Koretsky (2008)
  • MRI of Neural Circuits
  • Nature Clinical Practice Cardiovascular Medicine, 5, S71-78
  • 36) G. Zabow, S. Dodd, J. Moreland, and A.P. Koretsky (2008)
  • Micro-engineered Local Field Control for High-Sensitivity Multispectral MRI
  • Nature , 453, 1058-1063
  • 37) F. Hyodo, K.H. Chuang, A.G. Goloshevsky, A. Sulima, G.L. Griffiths, J.B. Mitchell, A.P. Koretsky, M.C. Krishna (2008)
  • Brain Redox Imaging Using Blood-Brain Barrier Permeable Nitroxide MRI Contrast Agent
  • J. Cereb. Blood Flow Metab. , 28, 1165-1174
  • 38) K-H Chuang, P. v. Gelderen, J. Bodurka, V.N. Ikonomidou, A. P. Koretsky, J. H. Duyn, S. L. Talagala (2008)
  • Mapping resting-state functional connectivity using perfusion MRI
  • Neuroimage, 40, 1595-1605
  • 39) K. M. Bennett, E. M. Shapiro, C. H. Sotak, and A. P. Koretsky (2008)
  • Controlled aggregation of ferritin to modulate MRI relaxivity
  • Biophysical J. , 95 , 342-351
  • 40) B. Stefanovic, E. Hutchinson, V. Yakovleva, V. Schram, J.T. Russell, L. Belluscio, A.P. Koretsky, and A.C. Silva (2008)
  • Functional Reactivity of Cerebral Capillaries
  • J. Cereb. Blood Flow Metab., 28, 961-972
  • 41) E.M. Shapiro and A.P. Koretsky (2008)
  • Micron Sized Iron Oxide Particles (MPIOs) for Cellular Imaging: More Bang for the Buck
  • "Nanoparticles in Biomedical Imaging, Emerging Technologies and Applications" eds J. Bulte and M. Modo in "Fundamental Biomedical Technologies Vol3" ed M. Ferrari, Springer, NY, 141-162
  • 42) A.C. Silva, J. H. Lee, C. W-H. Wu, I. Aoki, J. Tucciarone, G. Pelled, and A.P. Koretsky (2008)
  • Assignment of Cortical Laminar Architecture Using Manganese-Enhanced MRI
  • J. Neurosci Methods, 167, 246-257
  • 43) A G. Goloshevsky, A. C. Silva, S. J. Dodd and A. P. Koretsky (2008)
  • The Dependence of BOLD fMRI and Somatosensory Evoked Potentials on Stimulation of the Rat Forepaw with Various Pulse Waveforms
  • Brain Res, 1195, 67-76
  • 44) G. Goelman, G. Pelled, G., S. Dodd, and A.P. Koretsky, A.P. (2007)
  • Observation of Two Distinct spatial-temporal BOLD clusters During Sensory Stimulation in Rats
  • Neuroimage , 34 , 1230-1226
  • 45) Silva, A.C., Koretsky, A.P., and Duyn, J.H. (2007)
  • Functional MRI Impulse Response for BOLD and CBV Contrast in Rat Somatosensory Cortex
  • Magn Resonan Med , 57 , 1110-1118
  • 46) G. Pelled, K.H. Chuang, S.J. Dodd, and A.P. Koretsky (2007)
  • Functional MRI Detection of Bilateral Cortical reorganization in the Rodent Brain Following Complete Peripheral Nerve Dennervation
  • Neuroimage , 37, 262-273
  • 47) J.H. Duyn, P. van Gelderen, T.Q. Li, J.A. deZwart, A. P. Koretsky, and M. Fukunaga. (2007)
  • High-Field MRI of Brain Cortical Substructure Based on Signal Phase
  • Proc. Natl. Acad. Sci. USA , 104, 11513-11514
  • 48) E.M. Shapiro, L.N. Medford-Davis, T.M. Fahmy, C.E. Dunbar, and A.P.Koretsky. (2007)
  • Antibody-Mediated Cell Labeling of Peripheral T Cells with Micron Sized Particles of Iron Oxide (MPIOs) Allows Single Cell Detection by MRI
  • Contrast Media Mol. Imaging, 2, 147-153
  • 49) J. P. Sumner, R. Conroy, E.Shapiro, J. Moreland, and A.P. Koretsky. (2007)
  • Delivery of Fluorescence Probes Using Iron Oxide Particles as Carriers Enables In Vivo Labeling of Migrating Neural Precursors for MRI and Optical Imaging
  • J Biomed. Optics, 12, 5104-
  • 50) S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, and A. P. Koresky (2006)
  • BOLD and CBV weighted Functional MR Imaging of Rat Somatosensory System
  • Magn Resonan Med , 55, 316-324
  • 51) K. H. Chuang and A. P. Koretsky (2006)
  • Improved Neuronal Tract Tracing using Manganese Enhanced MRI with Fast T1 Mapping
  • Magn Resonan Med, 55, 604-611
  • 52) Ken-ichiro Matsumoto, Atsuko Matsumoto, Fuminori Hyodo, Alan P. Koretsky, Anastasia L. Sowers, James B. Mitchell, and Murali C. Krishna (2006)
  • High Resolution Mapping of Tumor Redox Status by Magnetic Resonance Imaging using Nitroxides as Redox-Sensitive Contrast Agents
  • Clinical Cancer Resarch , 12, 2455-2462
  • 53) E.B. Hutchinson, A. P. Koretsky , and A.C . Silva (2006)
  • Spatial Flow-Volume Dissociation of the Cerebral Microcirculatory Response to Mild Hypercapnia
  • Neuroimage , 32, 520-530
  • 54) 0T. T.Q. Li, P. van Gelderen, H. Merkle, L. Talagala, A.P. Koretsky, and J. Duyn (2006)
  • Extensive Heterogeneity in White Matter Contrast in High Resolution T2*-weighted MRI of the Human Brain at 7
  • Neuroimage , 32, 1032-1040
  • 55) E.M. Shapiro, O. Gonzalez, J. M. Garcia-Verdugo, A. Alvarez-Buylla, and A.P. Koretsky (2006)
  • Magnetic Resonance Imaging of the Migration of New Neuronal Presursors Generated in the Adult Rodent Brain
  • Neuroimage, 32, 1150-1157
  • 56) C.S. Landis, K. Yamanouchi, H. Zhou. S. Mohan, N. Roy-Chowdhury, D.A. Shafritz, A. P. Koretsky, J. Roy-Chowdhury, H. P. Hetherington, and C. Guha (2006)
  • Magnetic Resonance Spectroscopic Imaging Based Noninvasive Evaluation of Liver Repopulation by Transplanted Hepatocytes
  • Hepatology, 44, 1250-1258
  • 57) C. Du, N.D. Volkow, A.P. Koretsky, J.S. Fowler, and H. Benveniste. (2006)
  • Cocaine Increases the Intracellular Calcium Concentration in Brain Independently of its Cerebrovascular Effects
  • J. Neuroscience , 26, 11522-11531
  • 58) K. Chuang, A.P. Koretsky (2006)
  • Improved Neuronal Tract Tracing Using Manganese Enhanced Magnetic Resonance Imaging with Fast T1 Mapping
  • Magnetic Resonance in Medicine, 55, 604-611
  • 59) S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. Koretsky (2006)
  • BOLD and CBV-Weighted Functional Magnetic Resonance Imaging of the Rat Somatosensory System
  • Magnetic Resonance in Medicine, 55, 316-324
  • 60) I. Aoki, Y. Takahashi, K. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R.W. Childs, A.P. Koretsky (2006)
  • Cell Labeling for Magnetic Resonance Imaging with the T1 Agent Manganese Chloride
  • NMR in Biomedicine, 19, 50-59
  • 61) O. Rodriguez, S. Fricke, C. Chien, L. Dettin, J. Vanmeter, E.M. Shapiro, H. Dai, M. Casimiro, L. Lleva, J. Dagata, M.D. Johnson, M.P. Lisanti, A.P. Koretsky, C. Albanese (2006)
  • Contrast-Enhanced in Vivo Imaging of Breast and Prostate Cancer Cells by MRI
  • Cell Cycle, 5, 113-119
  • 62) E.M. Shapiro, K. Sharer, Skrtic, A.P. Koretsky (2006)
  • In Vivo Detection of Single Cells By MRI
  • Magnetic Resonance in Medicine, 55, 242-249
  • 63) E.K Shapiro, S. Skrtic, and A.P. Koretsky (2005)
  • Sizing it Up: Cellular MRI Using Micron Sized Particles
  • Magn Resonan Med , 53, 329-338
  • 64) J.H. Lee, A.C. Silva, H. Merkle, and A.P. Koretsky (2005)
  • Manganese Enhanced MRI (MEMRI) of Mouse Brain after Systemic Administration of MnCl2: Dose Dependence and Temporal Evolution of T1 Contrast
  • Magn Resonan Med, 53, 640-648
  • 65) T.C. Hu, T.F. Christian, A.H. Aletras, J.L. Taylor, A. P. Koretsky, and A.A. Arai (2005)
  • Manganese Enhanced MRI of Normal and Ischemic Canine Heart
  • Magn Resonan Med, 54, 196-200
  • 66) C. Du, A. P. Koretsky, I. Izrailtyan and H. Benveniste (2005)
  • Simultaneous Detection of Blood Volume, Oxygenation, and Intracellular Calcium Changes during Cerebral Ischemia and Reperfusion In Vivo using Photospectrometry
  • J. Cerebral Blood Flow and Metabolism, 25, 1078-1092
  • 67) U. Himmelreich, R. Weber, P. Ramos-Cabrer, S. Wegener, K. Kandal, E. M. Shapiro, A.P. Koretsky, M. Hoehn. (2005)
  • Improved Stem Cell MR Detectability in Animal Models by Modification of the Inhalation Gas
  • Molecular Imaging, 4, 104-109
  • 68) E. M. Shapiro, K. Sharer, S. Skrtic, and A. P. Koretsky (2005)
  • In Vivo Detection of Single Cells by MRI
  • Magn Resonan Med, 55, 242-249
  • 69) A.P. Koretsky, S.L. Talagala, S.D. Keilholz, A.C. Silva (2005)
  • MRI Detection of Regional Blood Flow Using Arterial Spin Labeling
  • Cambridge University Press, 119-140
  • 70) E.M. Shapiro, S. Skrtic, A.P. Koretsky (2005)
  • Sizing It Up: Cellular MRI Using Micron-Sized Iron Oxide Particles
  • Magnetic Resonance in Medicine, 53, 329-338
  • 71) G. Pelled, S.J. Dodd, A.P. Koretsky (2005)
  • Catheter Confocal Fluorescence Imaging and Functional Magnetic Resonance Imaging of Local and Systems Level Recovery in the Regenerating Rodent Sciatic Nerve
  • NeuroImage
  • 72) T.C. Hu, T.F. Christian, A.H. Aletras, J.L. Taylor, A.P. Koretsky, A.E. Arai (2005)
  • Manganese-Enhanced Magnetic Resonance Imaging of Normal and Ischemic Canine Heart
  • Magnetic Resonance in Medicine, 54, 196-200
  • 73) O. Speer, N. Back, T. Buerklen, D. Brdiczka, A.P. Koretsky, T. Wallimann, O. Eriksson (2005)
  • Octameric Mitochondrial Creatine Kinase Induces and Stabilizes Contact Sites Between the Inner and Outer Membranes
  • Biochem J, 385, 445-450
  • 74) J.A. de Zwart, A.C. Silva, P. van Gelderen, P. Kellman, M. Fukunaga, R. Chu, A.P. Koretsky, J.A. Frank, J.H. Duyn (2005)
  • Temporal Dynamics of the BOLD fMRI Impulse Response
  • NeuroImage, 24, 667-677
  • 75) U. Himmelreich, R. Weber, P. Ramos-Cabrer, S. Wegener, K. Kandal, E.M. Shapiro, A.P. Koretsky, M. Hoehn (2005)
  • Improved Stem Cell MR Detectability in Animal Models By Mdification of the Inhalation Gas
  • Molecular Imaging, 4, 104-109
  • 76) J. Lee, A.C. Silva, H. Merkle, A.P. Koretsky (2005)
  • Manganese-Enhanced Magnetic Resonance Imaging of Mouse Brain After Systemic Administration of MnCI2: Dose Dependent and Temporal of T1 Contrast
  • Magnetic Resonance in Medicine, 53, 640-648
  • 77) C. Du, A.P. Koretsky, I. Izrailtyan, H. Benveniste (2005)
  • Simultaneous Detection of Blood Volume, Oxegenation, and Intracellular Calcium Changes During Cerebral Ischemia and Reperfusion in Vivo Using Diffuse Reflectance and Fluorescence
  • Journal of Cerebral Blood Flow and Metabolism, 1-15
  • 78) J.H. Duyn, P. van Gelderen, S.L. Talagala, A.P. Koretsky, J.A. de Zwart (2005)
  • Technological Advances in MRI Measurement of Brain Perfusion
  • Journal of Magnetic Resonance Imaging, 22, 751-753
  • 79) C. Du, A.P. Koretsky, I. Izrailtyan, H. Benveniste (2005)
  • Simultaneous Detection of Blood Volume, Oxegenation, and Intracellular Calcium Changes During Cerebral Ischemia and Reperfusion in Vivo Using Photospectrometry
  • Journal of Cerebral Blood Flow and Metabolism, 25, 1078-1092
  • 80) A.C. Silva, J.H. Lee, I. Aoki, and A.P. Koretsky (2004)
  • Manganese-Enhanced Magnetic Resonance Imaging (MEMRI): Methodological and Practical Considerations
  • NMR Biomed, 17, 532-534
  • 81) A.P. Koretsky (2004)
  • New Developments in MRI
  • NeuroRx , 1, 155-164
  • 82) I. Aoki, Y.J.L. Wu, A.C. Silva, R.M. Lynch, and A.P. Koretsky (2004)
  • In Vivo Detection of Neuroarchitecture in the Rodent Brain Using Manganese Enhanced MRI
  • Neuroimage, 22, 1046-1059
  • 83) S. D. Keilholz, A.C. Silva, M. Raman, H. Merkle, and A.P. Koretsky (2004)
  • Functional MRI of the Rodent Somatosensory Pathway using Multislice Echo Planar Imaging
  • Magn. Resonan. Med, 52, 89-99
  • 84) J. H. Lee and A.P. Koretsky (2004)
  • Manganese Enhanced MRI
  • Curr. Pharm. Biotechnol. , 5, 529-537
  • 85) A.P. Koretsky, A.C. Silva (2004)
  • Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)
  • NMR in Biomedicine, 17, 527-531
  • 86) E.M. Shapiro, S. Skrtic, K. Sharer, J.M. Hill, C.E. Dunbar, A.P. Koretsky (2004)
  • MRI Detection of Single Particles for Cellular Imaging
  • Proc. Natl. Acad. Sci., 101, 10901-10906
  • 87) S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. Koretsky (2004)
  • Functional MRI of the Rodent Somatosensory Pathway Using Multisclice Echo Planar Imaging
  • Magnetic Resonance in Medicine, 52, 89-89
  • 88) G.A. MacGowan, C. Evans, T.C. Hu, D. Debrah, S. Mullet, H. Chen, C.F. Mctiernan, A.F. Stewart, A.P. Koretsky, S.G. Shroff (2004)
  • Troponin I Protein Kinase c Phosphorylation Sites and Ventricular Function
  • Cardiovascular Research, 63, 245-255
  • 89) I. Aoki, Y.L. Wu, A.C. Silva, R.M. Lynch, A.P. Koretsky (2004)
  • In Vivo detection of Neuroarchitecture in the Rodent Brain Using Manganese-Enhanced MRI
  • NeuroImage, 22, 1046-1059
  • 90) A.C. Silva, J. Lee, I. Aoki, A.P. Koretsky (2004)
  • Manganese-Enhanced magnetic Resonance Imaging (MEMRI): Methodological and Pratical Considerations
  • NMR in Biomedicine, 17, 532-543
  • 91) J. Lee, A.P. Koretsky (2004)
  • Manganese Enhanced Magnetic Resonance Imaging
  • Current Pharmaceutical Biotechnology, 5, 529-537
  • 92) C. Du, Y. Pan, G.A. MacGowan, A.P. Koretsky (2004)
  • Decreasing Motion Artifacts in Calcium-Dependent Fluorescence Transients from the Perfused Mouse Heart Using Frequency Filtering
  • Cell Calcium, 35, 144-156
  • 93) A.P. Koretsky (2004)
  • New Developments in Magnetic Resonance Imaging of the Brain
  • NeuroRx: The Journal of the American Society for Experimental NeuroTherapeutics, 1, 155-164
  • 94) C. Grabill, A.C. Silva, S.S. Smith, A. P. Koretsky, and T.A. Rouault (2003)
  • MRI Detection of Ferritin Overload and Associated Neuronal Pathology in Iron Regulatory Protein-2 Knockout Mice
  • Brian Res, 971, 95-106
  • 95) S-K. Jo, X. Hu, H. Kobayashi, M. Lizak, T. Miyaji, A. Koretsky, and R. Star. (2003)
  • Detection of Inflammation Following Renal Ischemia by Magnetic Resonance Imaging
  • Kidney International , 64, 43-51
  • 96) A. Hinds, J.M. Hill, E.M. Shapiro, M.O. Laukkanen, A.C. Silva, C.A. Combs, T.R. Varney, R. S. Balaban, A.P. Koretsky, C.E. Dunbar (2003)
  • Highly Efficient Endosomal Labeling of Progenitor and Stem Cells with Large Magnetic Particles Allows Magnetic Resonance Imaging of Single Cells K
  • Blood , 102, 867-872
  • 97) C. Grabill, A.C. Silva, S.S. Smith, A.P. Koretsky, T.A. Rouault (2003)
  • MRI Detection of Ferritin Iron Overload and Associated Neuronal Pathology in Iron Regulatory Protein-2 Knockout Mice
  • Brain Research, 971, 144-156
  • 98) K.A. Hinds, J.M. Hill, E.M. Shapiro, M.O. Laukkanen, A.C. Silva, C.A. Combs, T.R. Varney, R.S. Balaban, A.P. Koretsky, D.E. Cynthia (2003)
  • Highly Efficient Endosomal Labeling of Progenitor and Stem Cells with Large Magnetic Particles Allows Magnetic Resonance Imaging of Single Cells
  • Blood, 102, 144-156
  • 99) E.L. Barbier, S. Marrett, A. Danek, A. Vortmeyer, P. van Gelderen, J. Duyn, P. Bandettini, J. Grafman, A.P. Koretsky. (2002)
  • Imaging Cortical Anatomy by High Resolution MR at 3
  • Magn Resonan. Med, 48, 735-738
  • 100) D.E. Montgomery, B.M. Wolska, W.G. Pyle, B.B. Roman, J.C. Dowell, P.M. Buttrick, A.P. Koretsky, P. Del Nido, and R.J. Solaro (2002)
  • Alpha-Adrenergic Response and Myofilament Activity in Mouse Hearts Lacking PKC Phosphorylation Sites on Cardiac TnI
  • Am. J. Physiol. Heart Circ. Physiol., 282, H2397-H2405

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